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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Baillie Gifford & Co	[2023-03-31]	SOLE	16,670,409.0	16,670,409.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	10,748,375.0
BlackRock Inc.	[2023-03-31]	SOLE	10,366,798.0	10,631,857.0
Baillie Gifford & Co	[2023-03-31]	DFND	8,423,732.0	8,465,121.0
MIC Capital Management UK LLP	[2023-03-31]	SOLE	8,451,758.0	8,451,758.0
Kinnevik AB (publ)	[2023-03-31]	DFND	7,653,061.0	7,653,061.0
State Street Corp	[2023-03-31]	DFND	6,143,330.0	6,372,515.0
Data Collective IV GP, LLC	[2023-03-31]	SOLE	5,941,120.0	5,941,120.0
Laurion Capital Management LP	[2023-03-31]	SOLE	4,825,735.0	4,825,735.0
FMR LLC	[2023-03-31]	DFND	4,731,366.0	4,755,461.0
ARK Investment Management LLC	[2023-03-31]	SOLE	3,576,862.0	3,576,862.0
Platinum Investment Management Ltd	[2023-03-31]	SOLE	2,725,157.0	2,770,451.0
Geode Capital Management LLC	[2023-03-31]	DFND	2,743,484.0	2,743,484.0
MV Management Xi LLC	[2023-03-31]	SOLE	1,971,908.0	1,971,908.0
Credit Suisse AG	[2023-03-31]	DFND	1,564,017.0	1,582,373.0
Harvard Management Co Inc	[2023-03-31]	SOLE	1,509,254.0	1,509,254.0
Duquesne Family Office LLC	[2023-03-31]	DFND	1,385,950.0	1,385,950.0
Northern Trust Corp	[2023-03-31]	DFND	31,416.0	1,153,810.0
ArchPoint Investors	[2023-03-31]	SOLE	1,114,626.0	1,114,626.0
Comprehensive Financial Management LLC	[2023-03-31]	SOLE	1,109,395.0	1,109,395.0
Nuveen Asset Management LLC	[2023-03-31]	DFND	1,025,585.0	1,025,585.0
Charles Schwab Investment Management Inc	[2023-03-31]	SOLE	983,939.0	983,939.0
Cercano Management LLC	[2023-03-31]	SOLE	978,051.0	978,051.0
Citigroup Inc	[2023-03-31]	DFND	688,225.0	688,225.0
Dimensional Fund Advisors LP	[2023-03-31]	SOLE	637,414.0	664,133.0
Citadel Advisors LLC	[2023-03-31]	DFND	650,715.0	650,715.0
Millennium Management LLC	[2023-03-31]	SOLE	646,610.0	646,610.0
Bank of America Corp /DE/	[2023-03-31]	DFND	33,990.0	557,010.0
Bank of New York Mellon Corp	[2023-03-31]	DFND	435,421.0	528,955.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	523,700.0	523,840.0
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