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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
TCG Crossover Management LLC	[2025-06-30]	SOLE	2,676,580	2,676,580
Stempoint Capital LP	[2025-06-30]	SOLE	2,137,168	2,413,254
Nantahala Capital Management LLC	[2025-06-30]	SOLE	1,978,492	1,978,492
Vanguard Group Inc	[2025-06-30]	SOLE	0	1,748,833
Commodore Capital LP	[2025-06-30]	SOLE	1,575,000	1,575,000
JPMorgan Chase & Co	[2025-06-30]	DFND	748,862	748,862
Ikarian Capital LLC	[2025-06-30]	SOLE	601,703	601,703
Sphera Funds Management Ltd	[2025-06-30]	DFND	447,939	447,939
Adar1 Capital Management LLC	[2025-06-30]	SOLE	420,765	420,765
BlackRock, Inc.	[2025-06-30]	SOLE	416,889	416,889
Diadema Partners LP	[2025-06-30]	SOLE	404,122	404,122
Geode Capital Management LLC	[2025-06-30]	DFND	272,907	272,907
Almitas Capital LLC	[2025-06-30]	SOLE	261,399	261,399
Advisorshares Investments LLC	[2025-06-30]	SOLE	203,114	203,114
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	177,858
BML Capital Management LLC	[2025-06-30]	SOLE	0	150,000
Susquehanna International Group LLP	[2025-06-30]	OTR	115,368	115,368
Citadel Advisors LLC	[2025-06-30]	DFND	103,000	103,000
State Street Corp	[2025-06-30]	DFND	96,858	96,858
Jane Street Group LLC	[2025-06-30]	DFND	95,051	95,051
Two Sigma Investments LP	[2025-06-30]	SOLE	89,451	89,451
Persistent Asset Partners Ltd	[2025-06-30]	SOLE	86,819	86,819
Blair William & Co/IL	[2025-06-30]	SOLE	85,866	85,866
Northern Trust Corp	[2025-06-30]	DFND	48,093	48,093
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	43,362	43,362
Renaissance Technologies LLC	[2025-06-30]	SOLE	40,500	40,500
Marshall Wace LLP	[2025-06-30]	OTR	0	34,638
American Century Companies Inc	[2025-06-30]	DFND	31,063	31,063
Two Sigma Advisers LP	[2025-06-30]	SOLE	24,991	25,832
Charles Schwab Investment Management Inc	[2025-06-30]	SOLE	23,302	23,302
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