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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Opaleye Management Inc	[2025-06-30]	SOLE	12,600,000	12,600,000
Casdin Capital LLC	[2025-06-30]	SOLE	7,200,000	7,200,000
BlackRock, Inc.	[2025-06-30]	SOLE	6,923,124	7,135,938
FMR LLC	[2025-06-30]	DFND	4,584,987	4,610,357
Vanguard Group Inc	[2025-06-30]	SOLE	0	4,485,231
Aberdeen Group plc	[2025-06-30]	DFND	4,200,950	4,200,950
Nantahala Capital Management LLC	[2025-06-30]	SOLE	4,030,619	4,030,619
Telemark Asset Management LLC	[2025-06-30]	SOLE	4,000,000	4,000,000
Ameriprise Financial Inc	[2025-06-30]	DFND	0	2,550,806
Geode Capital Management LLC	[2025-06-30]	DFND	1,977,869	1,977,869
Pier Capital LLC	[2025-06-30]	SOLE	1,256,649	1,915,160
Baillie Gifford & Co	[2025-06-30]	DFND	1,685,664	1,685,664
State Street Corp	[2025-06-30]	DFND	1,514,508	1,613,338
Jacobs Levy Equity Management Inc	[2025-06-30]	SOLE	1,009,956	1,178,131
Federated Hermes Inc	[2025-06-30]	DFND	872,814	872,814
Renaissance Technologies LLC	[2025-06-30]	SOLE	755,486	755,486
Prescott Group Capital Management LLC	[2025-06-30]	SOLE	700,591	700,591
Northern Trust Corp	[2025-06-30]	DFND	646,275	646,583
Private Advisor Group LLC	[2025-06-30]	SOLE	0	522,913
Dimensional Fund Advisors LP	[2025-06-30]	SOLE	426,433	496,721
Morgan Stanley	[2025-06-30]	DFND	466,311	479,853
Post Resch Tallon Group Inc	[2025-06-30]	SOLE	0	467,301
Goldman Sachs Group Inc	[2025-06-30]	DFND	448,415	448,770
Franklin Resources Inc	[2025-06-30]	DFND	446,978	447,526
Royal Bank of Canada	[2025-06-30]	DFND	414,413	414,413
Mink Brook Asset Management LLC	[2025-06-30]	SOLE	321,711	321,711
Platinum Investment Management Ltd	[2025-06-30]	SOLE	316,383	316,383
Perkins Capital Management Inc	[2025-06-30]	SOLE	289,500	312,000
Nuveen, LLC	[2025-06-30]	DFND	300,852	300,852
Empire Financial Management Company LLC	[2025-06-30]	SOLE	0	295,000
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