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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Armistice Capital LLC	[2023-03-31]	SOLE	7,148,000.0	7,148,000.0
Janus Henderson Group PLC	[2023-03-31]	DFND	0.0	6,845,813.0
Deep Track Capital LP	[2023-03-31]	SOLE	6,147,268.0	6,147,268.0
BlackRock Inc.	[2023-03-31]	SOLE	5,828,681.0	6,047,916.0
State Street Corp	[2023-03-31]	DFND	4,237,449.0	4,367,877.0
Adage Capital Partners GP LLC	[2023-03-31]	SOLE	4,113,962.0	4,113,962.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,816,808.0
Macquarie Group Ltd	[2023-03-31]	SOLE	3,585,889.0	3,644,687.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	2,144,822.0	2,144,822.0
OrbiMed Advisors LLC	[2023-03-31]	DFND	419,700.0	1,744,300.0
Assenagon Asset Management S.A.	[2023-03-31]	SOLE	1,658,689.0	1,658,689.0
Kynam Capital Management LP	[2023-03-31]	SOLE	1,563,595.0	1,563,595.0
Pictet Asset Management Sa	[2023-03-31]	DFND	1.0	1,550,502.0
Jacobs Levy Equity Management Inc	[2023-03-31]	SOLE	1,261,734.0	1,465,752.0
Woodline Partners LP	[2023-03-31]	SOLE	1,439,699.0	1,439,699.0
Rock Springs Capital Management LP	[2023-03-31]	SOLE	1,276,650.0	1,276,650.0
Sofinnova Investments Inc	[2023-03-31]	SOLE	1,263,721.0	1,263,721.0
Geode Capital Management LLC	[2023-03-31]	DFND	1,216,574.0	1,216,574.0
JPMorgan Chase & Co	[2023-03-31]	DFND	700,914.0	1,133,019.0
Millennium Management LLC	[2023-03-31]	SOLE	1,124,338.0	1,124,338.0
Great Point Partners LLC	[2023-03-31]	DFND	0.0	1,003,000.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	982,591.0	999,491.0
Laurion Capital Management LP	[2023-03-31]	SOLE	984,961.0	984,961.0
Citadel Advisors LLC	[2023-03-31]	DFND	960,199.0	960,199.0
Morgan Stanley	[2023-03-31]	DFND	863,193.0	893,870.0
Finepoint Capital LP	[2023-03-31]	SOLE	875,221.0	875,221.0
Bank of America Corp /DE/	[2023-03-31]	DFND	12,418.0	817,825.0
Polar Asset Management Partners Inc	[2023-03-31]	SOLE	798,190.0	798,190.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	764,519.0	791,228.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	629,400.0	721,600.0
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