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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Janus Henderson Group PLC	[2025-06-30]	DFND	0	9,541,270
Armistice Capital LLC	[2025-06-30]	SOLE	8,876,000	8,876,000
BlackRock, Inc.	[2025-06-30]	SOLE	7,924,139	8,168,951
Vanguard Group Inc	[2025-06-30]	SOLE	0	5,806,026
Macquarie Group Ltd	[2025-06-30]	SOLE	4,976,270	5,097,482
State Street Corp	[2025-06-30]	DFND	3,235,138	3,483,176
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	2,784,000	2,784,000
Renaissance Technologies LLC	[2025-06-30]	SOLE	2,495,114	2,495,114
Emerald Advisers LLC	[2025-06-30]	SOLE	1,567,778	2,091,360
Geode Capital Management LLC	[2025-06-30]	DFND	2,003,701	2,003,701
Rock Springs Capital Management LP	[2025-06-30]	SOLE	1,908,208	1,908,208
Bank of America Corp /DE/	[2025-06-30]	DFND	26,621	1,701,393
Morgan Stanley	[2025-06-30]	DFND	1,551,856	1,568,544
Goldman Sachs Group Inc	[2025-06-30]	DFND	1,554,469	1,556,852
Kynam Capital Management LP	[2025-06-30]	SOLE	1,540,691	1,540,691
Eversept Partners LP	[2025-06-30]	SOLE	1,315,033	1,315,033
Nuveen, LLC	[2025-06-30]	DFND	1,170,732	1,194,335
RA Capital Management LP	[2025-06-30]	SOLE	1,150,000	1,150,000
Emerald Mutual Fund Advisers Trust	[2025-06-30]	SOLE	1,141,428	1,141,428
D. E. Shaw & Co., Inc.	[2025-06-30]	DFND	1,111,950	1,130,750
Assenagon Asset Management S.A.	[2025-06-30]	SOLE	1,103,075	1,103,075
FMR LLC	[2025-06-30]	DFND	1,063,818	1,067,773
Two Sigma Advisers LP	[2025-06-30]	SOLE	1,005,300	1,057,700
Frazier Life Sciences Management LP	[2025-06-30]	SOLE	1,002,092	1,002,092
Affinity Asset Advisors LLC	[2025-06-30]	SOLE	970,000	970,000
Citadel Advisors LLC	[2025-06-30]	DFND	959,257	959,257
Two Sigma Investments LP	[2025-06-30]	SOLE	918,713	918,713
Aberdeen Group plc	[2025-06-30]	DFND	896,594	896,594
Ensign Peak Advisors, Inc	[2025-06-30]	SOLE	858,834	858,834
Perceptive Advisors LLC	[2025-06-30]	SOLE	834,252	834,252
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