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Type	Result	AUM ($BB)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
FMR LLC	[2023-03-31]	DFND	10,921,578.0	10,922,748.0
State Street Corp	[2023-03-31]	DFND	5,269,544.0	5,280,944.0
Millennium Management LLC	[2023-03-31]	SOLE	3,837,996.0	4,404,296.0
Vanguard Group Inc	[2023-03-31]	SOLE	0.0	3,976,087.0
Susquehanna International Group LLP	[2023-03-31]	DFND	1,343,308.0	2,484,708.0
BlackRock Inc.	[2023-03-31]	SOLE	1,989,606.0	2,040,278.0
Boxer Capital, LLC	[2023-03-31]	OTR	2,000,000.0	2,000,000.0
Viking Global Investors LP	[2023-03-31]	SOLE	1,955,063.0	1,955,063.0
Wasatch Advisors LP	[2023-03-31]	SOLE	1,507,239.0	1,705,444.0
Laurion Capital Management LP	[2023-03-31]	SOLE	1,697,352.0	1,697,352.0
Point72 Asset Management LP	[2023-03-31]	DFND	0.0	1,393,335.0
Deerfield Management Company LP Series C	[2023-03-31]	DFND	1,125,000.0	1,125,000.0
Great Point Partners LLC	[2023-03-31]	DFND	0.0	1,080,000.0
Cormorant Asset Management LP	[2023-03-31]	DFND	1,050,000.0	1,050,000.0
Citadel Advisors LLC	[2023-03-31]	DFND	1,039,292.0	1,039,292.0
RTW Investments LP	[2023-03-31]	SOLE	1,000,000.0	1,000,000.0
Two Sigma Advisers LP	[2023-03-31]	SOLE	832,028.0	896,528.0
Morgan Stanley	[2023-03-31]	DFND	555,896.0	878,611.0
Perceptive Advisors LLC	[2023-03-31]	SOLE	871,747.0	871,747.0
Goldman Sachs Group Inc	[2023-03-31]	DFND	869,956.0	869,986.0
Geode Capital Management LLC	[2023-03-31]	DFND	863,232.0	863,232.0
Bank of America Corp /DE/	[2023-03-31]	DFND	10,721.0	858,245.0
D. E. Shaw & Co., Inc.	[2023-03-31]	DFND	840,655.0	850,055.0
Renaissance Technologies LLC	[2023-03-31]	SOLE	761,200.0	761,200.0
Integral Health Asset Management LLC	[2023-03-31]	SOLE	727,100.0	727,100.0
Affinity Asset Advisors LLC	[2023-03-31]	SOLE	716,149.0	716,149.0
Two Sigma Investments LP	[2023-03-31]	SOLE	695,705.0	695,705.0
Ghost Tree Capital LLC	[2023-03-31]	SOLE	600,000.0	600,000.0
683 Capital Management LLC	[2023-03-31]	DFND	580,000.0	580,000.0
Citigroup Inc	[2023-03-31]	DFND	565,041.0	565,041.0
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