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Type	Result	AUM ($B)

Form 13F Holdings
Firm	Period	DFND	Voting	Shares
Janus Henderson Group PLC	[2025-06-30]	DFND	0	5,308,009
Vivo Capital LLC	[2025-06-30]	SOLE	3,958,294	3,958,294
Adage Capital Partners GP LLC	[2025-06-30]	SOLE	3,575,964	3,575,964
FMR LLC	[2025-06-30]	DFND	3,336,788	3,337,858
BlackRock, Inc.	[2025-06-30]	SOLE	2,770,929	2,844,747
Vanguard Group Inc	[2025-06-30]	SOLE	0	2,404,318
Avoro Capital Advisors LLC	[2025-06-30]	SOLE	2,050,000	2,050,000
Citadel Advisors LLC	[2025-06-30]	DFND	1,666,761	1,666,761
Susquehanna International Group LLP	[2025-06-30]	OTR	412,707	1,567,507
Westfield Capital Management Co LP	[2025-06-30]	SOLE	1,028,230	1,429,756
State Street Corp	[2025-06-30]	DFND	1,278,172	1,404,983
Holocene Advisors LP	[2025-06-30]	SOLE	1,153,048	1,153,048
Nantahala Capital Management LLC	[2025-06-30]	SOLE	1,001,350	1,001,350
Caption Management LLC	[2025-06-30]	SOLE	926,187	926,187
Geode Capital Management LLC	[2025-06-30]	DFND	902,396	902,396
Carlyle Group Inc.	[2025-06-30]	DFND	0	860,980
Polar Capital Holdings Plc	[2025-06-30]	DFND	817,500	817,500
Boothbay Fund Management LLC	[2025-06-30]	OTR	0	686,800
Emerald Advisers LLC	[2025-06-30]	SOLE	504,918	672,908
Millennium Management LLC	[2025-06-30]	SOLE	633,721	658,721
Pictet Asset Management Holding SA	[2025-06-30]	SOLE	588,178	652,052
Invesco Ltd.	[2025-06-30]	DFND	0	645,974
Wellington Management Group LLP	[2025-06-30]	DFND	0	621,038
Capital World Investors	[2025-06-30]	DFND	614,833	614,833
Commodore Capital LP	[2025-06-30]	SOLE	610,000	610,000
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.	[2025-06-30]	SOLE	502,374	502,374
Artia Global Partners LP	[2025-06-30]	SOLE	494,424	494,424
Bank of New York Mellon Corp	[2025-06-30]	DFND	454,761	485,865
Siren, L.L.C.	[2025-06-30]	DFND	467,342	467,342
Alyeska Investment Group LP	[2025-06-30]	SOLE	445,352	445,352
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